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La Maison Profumo is centrally located, among the most prestigious in the city. Just a few steps from the Colosseum, they are located in the historic setting of Via San Giovanni in Laterano, the street that connects Colosseum Square to the Basilica of San Giovanni, the most important Basilica in the Christian West.

Most of the rooms overlook the ancient Basilica of San Clemente, immersed in what can be considered one of the most lively and attractive historical quarters of the city. The whole area lives a life of its own, escaping the traffic of the City, and walking through its streets one can rediscover the ancient pleasures of yesteryear. Charming artisan shops and small restaurants teem in the neighbourhood, providing visitors with a relaxed feeling and a familiarity uncommon in the rest of the Capital.